ESPE Yearbook of Paediatric Endocrinology

PrefaceOver the last twelve months important clinical and basic research in the field of thyroidology was published. Here a rapid overview on important topics in the field: A better understanding of carcinogenesis through ionizing radiation came from a large genomic study on papillary thyroid cancer samples of patients exposed to radioactive iodine as children in 1986 in Chernobyl. A remarkable step in regeneration of thyroid function in thyroidectomized...

Introduction: Over the last year, the most important advances in pediatric thyroidology were made in the field of pediatric differentiated thyroid cancer. Two articles provided evidence for the importance of molecular diagnostics for outcome prediction and targeted therapies in children with radioactive iodine refractory disease. A large long-term study reported for the first time on risk of secondary malignancies in patients with differentiated thyroid carcinoma treated with ...

Preface: The highlight of the year in basic thyroidology is the description of the molecular architecture of the thyroglobulin dimer. For decades, small pieces of knowledge were accumulated that are now integrated into the complete picture of the thyroglobulin glycoprotein three-dimensional structure as well as the few key functional hormonogenic tyrosine residues which allow thyroxine and tri-iodothyronine synthesis. Genetic research revealed new and unexpected molecular mech...

Preface: This year’s THYROID chapter aims at summarizing important new knowledge on all aspects of the thyroid axis from fundamental and clinical research relevant for scientists and clinicians, ranging from studies on the function of primary cilia within the thyroid follicle over new genetic defects along the thyroid axis to new immunmodulatory therapeutic approaches for Graves’ disease. These new insights provide better molecular understanding of thyroid hormone re...